problem metabolizing NSAIDs impaired NSAID drug metabolism, which is a risk factor for gastrointestinal bleeding when taking any of these medications: aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib. You have one of these *CYP2C8*3 (rs11572080 and rs10509681) *CYP2C9*2 (rs1799853) *CYP2C9*3 (rs1057910)
| Bad | |
| 3.1 | |
| 20140719 |
obesity risk and 1.6x risk for T2D This genotype produces higher levels of the appetite-stimulating hormone ghrelin, increasing your risk of obesity and type-2 diabetes by roughly 60%.
more ...rs9939609 is a SNP in the fat mass and obesity associated FTO gene, aka the 'Fat Gene' The original paper describing it is here . [http://www.alzforum.org/new/detail.asp?id=1567 The researchers identified 10 different FTO SNPs in the first intron of the gene that associated with both BMI and type-2 diabetes. Because they all correlated with each other, they chose to examine one of the SNPs (rs9939609) in detail. rs9939609 has also been reported in a large study to be associated with type-2 diabetes. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.34 (CI 1.17-1.52), and for homozygotes, 1.55 (CI 1.3-1.84). In a different study, this SNP was found in a linkage block in the FTO gene with rs1121980; see rs1121980 for the association of th...
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| 3.1 | |
| 17.7% | |
| 0.3554 | |
| 292 | |
| FTO | |
| 16 | |
| 53786615 | |
| 3.1 | |
| 20150705 | |
| plus | |
| plus |
Intermediate warfarin metabolizer Approximately 30% of people are intermediate metabolizers of the popular anticoagulant Warfarin and would probably need a decreased dosage. This due to rs1799853 or rs1057910 respectively leading to the CYP2C9*2 or CYP2C9*3 alleles. For prodrugs that require activation by CYP2C9, an alternative treatment or increased dose should be considered. See also gs126
| 3 | |
| 20111003 |
R-L21 Y chromosome paternal ancestry positive for rs11799226(G) (L21) + tested Haplogroup R (Y-DNA) SNPs and are therefore part of the haplogroup defined by these SNPs ((R1b1b2a1a2f w/ the latest ISOGG tree) or a subhaplogroup User:Cariaso and User:Meightysix are members of this Haplogroup Y (Y-DNA)
| 3 | |
| 20110108 |
fully heterozygous, age related tasting variation You are heterozygous at all 3 of the SNPs which are known to influence the ability to taste bitterness. This means you are better than average at detecting bitter tastes while young, but that this ability will decrease to less than average during adulthood. As a child you will probably hate brussel sprouts, and by early adulthood will discover that olives and brussel sprouts now taste good. A 2010 study shows the change bitter sensitivity which occurs over the lifespan (from bitter sensitive to less so) is more common in people with this genoset. Children with this genotype could perceive a bitter taste at lower PROP concentrations than could heterozygous adults. The threshold for adolescents was intermediate. The 3 SNPs are rs10246939, rs1726866, rs713598 in the gene TAS2R38.
| 3 | |
| 20120426 |
Increased risk (41.6% of white men) of Atrial Fibrilliation in one copy of both SNPs reported by 23andMe. One copy of each of the two atrial fibrillation SNPs mentioned by 23andMe is defective. This affects the formation of the heart and gives a high risk of Atrial Fibrillation (quivering of the top part of the heart). It also seems to increase the risk of Cardioembolic ischemic stroke (blocked blood flow to the brain) although 23andMe doesn't mention that. For European men, 23andMe reports this as a 41.6% risk, compared to the 27.2% average. The risk is lower for women. Based on several quality studies, and confirmed for Europeans and partly for Asians. It's recommended that you eat a heart-healthy diet, and only drink alcohol in moderation, to lower the risk. See a doctor for more information.
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| 3 | |
| 20131206 |
Autoimmune disorder risk (lupus, celiac disease) due to 2 HLA-DRB1*0301 alleles
more ...In at least UK populations, and perhaps others, SNP rs2187668 is a tag SNP for the HLA-DRB1*0301 allele. The HLA-DRB1*0301 allele is the allele presenting the highest risk for developing lupus, and it appears to act in a dominant manner (i.e. inheriting 2 copies is no worse than inheriting 1 copy). In dbSNP orientation, the risk allele is rs2187668(A), with an odds ratio of 2.3x (CI: 1.7 - 3.2, permuted p < 0.0001). From individuals with the most common rs2187668(G;G) genotype, risk is reduced for celiac disease, with an odds ratio of 0.30x according to a study of ~800 patients. rs2187668(A) also tags the tightly linked DQB1*0201 allele, which in turn is linked to DQA1*0501; together, these are known as the DQ2.5 haplotype. This is the most common haplotype associated with celiac diseas...
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| 3 | |
| 0% | |
| 0.08356 | |
| 9 | |
| HLA-DQA1 | |
| 6 | |
| 32638107 | |
| 3 | |
| 20150103 | |
| minus | |
| minus |
*more rapid progression to full-blown AIDS and probably increased susceptibility to HIV infection *reduced risk of acute coronary events *increased risk of age related macular degeneration
more ...rs3732378 VAL249ILE is tightly linked to neighboring rs3732379 THR280MET The protein receptor with both variant amino acids is known as CX3CR1-M280. the minor alleles of this pair are associated with *more rapid progression to full-blown AIDS and probably increased susceptibility to HIV infection *reduced risk of acute coronary events *increased risk of age related macular degeneration [OMIM:?]
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| Bad | |
| 3 | |
| 255 | |
| 2.7% | |
| 0.09688 | |
| 12 | |
| CX3CR1 | |
| 3 | |
| 39265671 | |
| 3 | |
| 20150707 | |
| plus | |
| plus |
introversion; depression resistant; impaired motor skills learning Met/met (higher risk) variant of the Val66Met snp in the BDNF gene that codes for brain-derived neurotrophic factor. Met/met is associated with susceptibility to neuropsychiatric disorders. associated with introversion This genotype may provide resistance to depression when subjected to repeated defeat blog summary On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. Wired discusses the research as does 23andMe blog.
more ...rs6265, also known as Val66Met, is a SNP in brain-derived neurotrophic factor BDNF gene. The more common G allele encodes the Val, while the A allele encodes Met. Met/A allele associated with introversion The A allele may also be protective against depression when subjected to repeated defeat g2b2mh blog On a driving-based motor learning task subjects with this genotype showed greater error during short-term learning and poorer retention over 4 days, relative to subjects without the polymorphism. The presence of this BDNF polymorphism is associated with differences in brain motor system function, altered short-term plasticity, and greater error in short-term motor learning. Wired discusses the research as does 23andMe blog. Alzheimer's disease risk for non ApoE4 carriers is affected by the...
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| Bad | |
| 3 | |
| 255 | |
| 2.7% | |
| 0.2287 | |
| 189 | |
| BDNF | |
| 11 | |
| 27658369 | |
| 3 | |
| 20150717 | |
| minus | |
| minus |